رفرنس استاندارد کلسیم فولینات برای تناسب سیستم

Calcium folinate for system suitability

Y0002071

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لینک کالا در سایت EP ( کلیک کنید )

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Analytical Chemistry

Y0002071

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Key Documents

• SDS

• COO/COA

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Y0002071

Calcium folinate for system suitability

رفرنس استاندارد

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Folinic acid calcium salt hydrate, 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt

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10 MG

€141.00

About This Item

Empirical Formula (Hill Notation):

C20H21CaN7O7 · xH2O

CAS Number:

1492-18-8

Molecular Weight:

511.50 (anhydrous basis)

Beilstein:

5723924

UNSPSC Code:

41116107

NACRES:

NA.24

Y0002071

€141.00

Availability

Available to ship onJanuary 02, 2025Details

To order products, please contact your local dealer.

biological source

synthetic

grade

pharmaceutical primary standard

Agency

EP

API family

folic acid

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13

InChI

1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1

InChI key

KVUAALJSMIVURS-ZEDZUCNESA-L

Calcium folinate, the reduced form of folic acid, finds application in the treatment of methotrexate overdose and in high-dose methotrexate chemotherapy as a chemotherapy protective drug to bring down the latter′s toxicity. When combined with fluorouracil, it is reported to be effective in the management of bowel cancer wherein it acts by inhibiting thymidylate synthase and augmenting the effect of fluorouracil.[1]

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Calcium folinate for system suitability may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.[2]

Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

فروش رفرنس استاندارد

Detailed view of Calcium folinate for system suitability CRS 

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How to read this table

• BVS Batch Validity Statement.
  
  
  1- Catalogue Code designates the catalogue code that has been assigned to each Reference Standard.
  
  2- Name lists the name of each item as designated in the European Pharmacopoeia (English version) and/or on the label.
  If the suffix psy, narc, Drug Precursor, MOT(biotox) or *ODS appears, export authorizations are mandatory in France or according to European regulations.
  Import permit / license may be needed in your country. For more details, please refer to our Specific Terms and Conditions: reference standards
  
  3- Current Batch Number shows the batch of the selected item being distributed as of the date of this online catalogue.
  Print BVS for more information.
  
  4- Unit quantity per vial is the quantity of material provided in each container.
  
  5- Number of vials per sales unit is for one item ordered the number of container(s) supplied, when more than one container is supplied for each per item in the order.
  
  6- Used in monograph(s) lists the European pharmacopoeia monograph(s) and/or general method(s) prescribing the use. For more details, see leaflet.
  
  7- Assigned content See leaflet for the value and explanations on use.
  
  8- Additional information includes chemical name of an impurity, synonym and information in case of suppression or replacement of a standard.
  
  9- Leaflet is made available for Reference Standard for the prescribed European Pharmacopoeia use(s). Click on the hyperlink to download. Leaflet is accessible also via BVS.
  
  10- Chemical hazard EDQM provides Safety Data Sheet (SDS) when hazard is identified in accordance UNECE/GHS as enacted in the EU.
  
  11- Biological hazard EDQM provides a safety data statement when hazard is identified in accordance with Directive 2000/54/EC.
  
  12- SDS product code : this code corresponds to the reference of the applicable document (safety data sheet or bio-hazard statement).
  
  13- The CAS Registry Number® is based on information received from the supplier and on current knowledge. CAS Registry Number® is a registered trademark of the American Chemical Society.
  
  14- Origin To be checked if import permit is required in your country.
  
  15- Proposed Import HS code To be checked for your import customs clearance. The HS code stated for each product is a proposal of the Council of Europe (EDQM). The accuracy of HS code cannot be guaranteed.
  The importer shall be personally responsible for the tariff classification in the country of import and will assume the ensuing regulatory, fiscal, health and safety obligations.
  
  16- EDQM long term Storage conditions recommended and in most cases more stringent than those given in the monograph.
  
  17- Dispatching conditions includes information on special dispatching conditions required by the item.
  
  18- UN Code Classification for the shipment of the dangerous goods. Please refer to (Transport information) of the SDS.
  
  19- Shipping group A parcel can only be composed of products with the same shipping group. In addition, dangerous goods will be split according to UN code.
  
  20- Price 2.5€ to be added per sales unit for handling.
  
  21- Sales restriction are applied in such a way that as many customers as possible will receive at least some of the limited quantities.