کانامایسین سیگما Kanamycin sulfate from Streptomyces kanamyceticus K4000
کانامایسین سیگما
Kanamycin sulfate from Streptomyces kanamyceticus
K4000
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K4000
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K4000
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Kanamycin sulfate from Streptomyces kanamyceticus
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Animal Component-free
Synonym(s):
Kanamycin A, Kanamycin sulfate salt
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1 G
€63.10
5 G
€211.00
25 G
€818.00
50 G
€1,380.00
About This Item
Empirical Formula (Hill Notation):
C18H36N4O11 · H2O4S
CAS Number:
Molecular Weight:
582.58
EC Number:
MDL number:
UNSPSC Code:
51281654
PubChem Substance ID:
NACRES:
NA.76
K4000-1G
€63.10
Availability
Available to ship onDecember 24, 2024Details
To order products, please contact your local dealer.
Properties
biological source
Streptomyces kanamyceticus
Quality Level
form
powder
potency
≥750 μg per mg (dry basis)
color
white to off-white
solubility
H2O: 50 mg/mL, clear, colorless to faintly yellow
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma
Mode of action
protein synthesis | interferes
SMILES string
OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
InChI
1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChI key
OOYGSFOGFJDDHP-KMCOLRRFSA-N
Description
General description
Kanamycin Sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus.
Application
Kanamycin sulfate is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL. Kanamycin sulfate from Streptomyces kanamyceticus has been used:
in the research of bacterial antibiotic resistance[1][2]
in the research on the effect of different antibiotics on bud regeneration[3]
Biochem/physiol Actions
Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.
Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.
Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
Features and Benefits
High quality antibiotic suitable for mulitple research applications
Preparation Note
Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.
Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.
Storage and Stability
Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Safety Information
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
P201 - P202 - P280 - P308 + P313 - P405 - P501
Hazard Classifications
Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Documentation
Certificate of AnalysisCertificate of Origin
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
0000399707
0000370427
0000370426
0000370425
0000370424